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KMID : 0390220070180020190
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Journal of Clinical Otolaryngology, Head and Neck Surgery
2007 Volume.18 No. 2 p.190 ~ p.194
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A Immunohistochemical Study of Expression of Galectin-3
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Lee Jae-Hoon
Yun Ki-Jung
Lee Jung-Hun
Lee Sang-Heon
Jeong Jung-Rae
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Abstract
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Background and Objectives：Nasal polyp is benign growth processes in the nasal and sinus mucosa. Galectin-3 is a beta-galactoside binding protein, of which the major function is not fully elucidated. Galectin-3 expression can be linked to the benign growth activity of nasal polyps due to an anti-apoptotic effector activity. To illustrate the role of the galectin-3 in the nasal polyp, we investigated the expressive pattern of the galectin-3 in nasal polyp and the influence of corticosteroid on its expression.
Materials and Methods：The study materials were 30 specimens of nasal polyp (steroid user：14 cases, steroid non-user：16 cases) taken from 30 patients during endoscopic sinus surgery and 10 cases of normal nasal mucosa of the inferior turbinate as control. The galectin-3 expression was assessed by immunohistochemical staining.
Results： The galectin-3 expression in the surface epithelium, lamina propria and glands was markedly higher in nasal polyps than in turbinates. There was significantly different in the expression of galectin-3 between the steroid user group and the non-user group of nasal polyps. The galectin-3 expression in the surface epithelium and glands was markedly lower in steroid user group than in non-user group.
Conclusion：Galectin-3 may be associated with growth of nasal polyp. Oral corticosteroids may exert a beneficial effect by significantly reducing the levels of galectin-3 in nasal polyp.
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KEYWORD
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Nasal polyp, Galectin-3
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